What next for preimplantation genetic screening? A clinician's perspective
نویسندگان
چکیده
منابع مشابه
What next for preimplantation genetic screening? A polar body approach!
Screening of human preimplantation embryos for numerical chromosome abnormalities has been conducted mostly at the preimplantation stage using fluorescence in situ hybridization. However, it is clear that preimplantation genetic screening (PGS) as it is currently practiced does not improve live birth rates. Therefore the ESHRE PGS Task Force has decided to start a proof of principle study with ...
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Many published papers suggest a favourable impact of preimplantation genetic screening (PGS) on implantation and pregnancy rates, but more recent randomized studies have not confirmed, or could not conclude, that PGS actually improved implantation rates. Team inexperience in embryo screening has been mentioned as the origin of the discrepancies; thus some clinicians allege a need for more power...
متن کاملNEW DEBATE What next for preimplantation genetic screening?
Joyce Harper1,13, Karen Sermon2, Joep Geraedts3, Katerina Vesela4, Gary Harton5, Alan Thornhill6, Tugce Pehlivan7, Francesco Fiorentino8, Sioban SenGupta1, Christine de Die-Smulders9, Cristina Magli10, Celine Moutou11 and Leeanda Wilton12 UCL Centre for PGD, Institute for Women’s Health, University College London, 86-96 Chenies Mews, WC1E6HX London, UK; Department of Embryology and Genetics, Vr...
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Blastocysts more commonly have a normal karyotype than cleavage-stage embryos do. Moreover, blastocysts have also made a metabolic transition from catabolism and recycling of the oocyte's reserves and resources, processes that fuel the first 3 days of cleavage. Although not all blastocysts are karyotypically equal, it is still to be determined to what extent a mosaic karyotype might be a normal...
متن کاملWhat next for preimplantation genetic screening? Randomized clinical trial in assessing PGS: necessary but not sufficient.
The randomized clinical trial (RCT) is a powerful experimental design that when properly executed produces generalizable results. Conducting a RCT becomes complex when technical skills are required. Without requisite skills, a RCT may yield misleading results, an elegant RCT unwittingly generating spurious results due to technical inexperience. This pitfall is applicable to procedures used to e...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2008
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/den241